The incident occurred on Hwy. 101 near Postell Hughes Drive in Gray Court.
The driver of the vehicle was driving a 2005 Chevrolet truck and was not injured. The driver of the bicycle died at the scene.
According to the SCHP, both units were driving north on Hwy. 101 near I-385 when the truck hit the rear of the bicycle.
Laurens County Coroner Nick Nichols identified the victim as Cahri Abozahri, 22, of 102 Dad's Place in Gray Court.
The incident is under investigation by the SCHP.